ABSTRACT
Statement of the Problem: Fixed orthodontic appliances predispose patients to dental caries. Use of mouthrinses has been introduced as the effective way for reducing dental plaque accumulation
Purpose: The aim of this study was to compare the effects of Persica mouthwash and Chlorhexidine [CHX] on colonization of Streptococcus mutans [S. mutans] on fixed orthodontic O-rings
Materials and Method: Thirty patients with fixed orthodontic appliances and proper oral hygiene were randomly provided by CHX and Persica and trained to use these mouthwashes according to the manufacturer's instruction. Sampling was carried out right before and 4 weeks after mouthrinsing treatment. The mean amounts of S. mutans colonies in these groups were compared
Results: Comparison of S. mutans colonization within each group revealed both mouthrinses to be efficient. However, this difference was found to be significant only in CHX group
Conclusion: Persica cannot be a good alternative mouthwash and patients on orthodontic treatment are still recommended to use CHX
ABSTRACT
Four commonly used spices plants in Iran were evaluated for cytotoxicity effect using Brine Shrimp Lethality [BSL] assay. Essential oils and various extracts of Heracleum persicum, Nigella arvensis, Cinnamomum zeylanicum and Zingiber officinale were assessed by two methods of disk and solution of BSL. Data were processed in probit-analysis program to estimate LC50 values. All of the tested fractions have exhibited more cytotoxicity in the solution method. Essential oils of H. persicum and C. zeylanicum have shown the most cytotoxicity with LC50 values 0.007 and 0.03 microg/ml respectively. None of aqueous extracts showed significant cytotoxicity. The analysis of the essential oil of H. persicum showed the hexyl butyrate and octyl acetate as the main compounds. These results suggest some limitation for using of these spices in diet. Furthermore, these plants could be considered as a source of cytotoxic compounds which might be studied in more details